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چکیده
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Chiral amines and their derivates are essential building blocks for the preparation of many pharmaceutical and biologically active molecules [1]. They are used directly as resolving agents, building blocks, or chiral auxiliaries [2]. The discovery and development of new catalytic reactions that lead to C-C bond formation by the addition of organometallic reagents to C=N of imine are important developments in efficient processes for chemical synthesis [3]. Asymmetric catalysis has emerged as one of the most effective synthetic methods for the preparation of enantiopure compounds [4]. Lots of Methods for preparing chiral aromatic amines have been developed using a suitable chiral catalyst. A large number of catalytic systems using transition metal complexes have been developed for the direct carbon-carbon bond formation of aromatic amines [5]. In this work, to develop a new method of chiral amine formation using a chiral catalyst that can be easily recycled and reused, we have investigated the catalytic activity of nanomagnetic L-Cysteine coated by copper metal catalyst on arylation of imines 1 by Phenyl boronic acid 2 (Scheme 1). The structure and morphology of prepared nanomagnetic catalysts were characterized by EDAX, SEM, and FT-IR. The structure of chiral products is identified by IR, 1H NMR, and 13C NMR spectroscopies. The enantiomeric excess (ee) of chiral products is also detected by the polarimeter.
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