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Title
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Electrocatalytic Dehydrogenation of 1,4-dihydropyridines and 2,3- dihydroquinazolinones Using 4-phenylurazole as a Novel Redox Mediator Under Mild Conditions
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Type
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JournalPaper
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Keywords
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electrocatalytic oxidation; 1,4-dihydropyridines; 2,3-dihydroquinazolinones; electrocatalytic mediator
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Abstract
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The electrochemical oxidation of 1,4-dihydropyridines and 2,3-dihydroquinazolinones by 4-phenyl urazole (4-PU) as an effective mediator to produce selective products with excellent yields in a phosphate buffer (pH = 3) solution under mild reaction conditions is presented. The electrochemical reactions were performed in a mixture of acetonitrile: water 80:20 as solvent under a constant potential of 0.6 V vs SCE. The electrocatalytic properties of the mediator were investigated by the cyclic voltammetry technique. At the applied potential, the generation/regeneration of 1,2,4-triazole-3,5-diones/4-phenyl triazoledione occurred, and the oxidation of 1,4-dihydropyridines and 2,3-dihydroquinazolinones derivatives at reduced overpotential led to the formation of products with high efficiency. The presented electrogenerated mediator is promising for the selective electrocatalytic oxidative dehydrogenation of N-heterocycle compounds under mild conditions.
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Researchers
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Amin Rostami (Fourth Researcher), Farzad Nikpour (Third Researcher), Abdollah Salimi (Second Researcher), Azad Bani (First Researcher)
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