عنوان	Application of layered double hydroxides as laccase mimicking nanozymes in the oxidation of 2,3-dihydroquinazolin-4(1H)-ones and hantzsch 1,4-dihydropyridines
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	layered double hydroxides , laccase mimicking, nanozymes, oxidation, 2,3-dihydroquinazolin-4(1H)-ones, 1,4-dihydropyridines
چکیده	This study explores the innovative use of copper–manganese–iron layered double hydroxides nanozyme (CuMnFe-LDHzyme) in aerobic oxidation of N-heterocyclic compounds. The successful fabrication of CuMnFe-LDHzyme was substantiated through X-ray powder diffraction (XRD) analysis. Energy-dispersive X-ray (EDX) spectroscopy was employed to ascertain the presence of the metal ion composition. Morphological alterations were investigated using scanning electron microscopy (SEM). Inspired by the laccase-mediated system, herein the combination of CuMnFe-LDHzyme with 2,3-dichloro-5,6-dicyano- 1,4-benzoquinone (DDQ) or 4-phenyl urazole (4-PU) as a cooperative catalytic system was used for the oxidative synthesis of quinazolinones (60–95% yield) and pyridines (65–95% yield) using O2 as ideal oxidants in acetonitrile at 50–60 °C. The CuMnFe-LDHzyme not only mimics the functionality of laccase enzymes but also enhances catalytic activity through its unique layered structure, facilitating electron transfer and increasing reaction efficiencyWe believe that synthesized CuMnFe-LDHzyme superior tolerance to variations in temperature, ionic strength, and storage conditions, as well as excellent recyclability compared to naturally occurring laccase counterparts.
پژوهشگران	نادیا فریشی (نفر اول)، امین رستمی (نفر دوم)