عنوان	Alterations in circular RNAs circOprm1 and circSerpini in the striatum are associated with changes in spatial working memory performance after morphine dependence and withdrawal in rats
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	circular RNAs, microRNAs, Morphine dependence, Withdrawal, Working memory, Striatum
چکیده	Modulating role of circRNAs and microRNAs in neurobiological changes induced by drug exposure remains unclear. We examined alterations in some circRNAs and microRNAs in the striatum after morphine dependence and withdrawal and their associations with the changes in spatial working memory performance. Male Wistar rats were used in which 10 days morphine exposure induced tolerance. Withdrawal effects were assessed 30 days after stopping morphine exposure. Spatial working memory was assessed using a Y maze test on days 1 and 10 of the drug exposure and 30 days after withdrawal. The gene and protein expression were assessed after dependence and withdrawal. The results revealed that 10 days morphine exposure impaired working memory, which partially reinstated after withdrawal. After 10 days morphine exposure, significant increases in Oprm1 gene and OPRM1 protein levels were detected, which persisted even after withdrawal. The expression of circOprm1 and miR-339-3p decreased in the morphine-dependent group, but the
پژوهشگران	شمس الدین احمدی (نفر اول)، عبدالباسط ولی (نفر دوم)، سمیرا امیری (نفر سوم)، دانش رستمی (نفر چهارم)، محمد مجیدی (نفر پنجم)، کریم رحیمی (نفر ششم به بعد)