مشخصات پژوهش

عنوان	Injectable Antibacterial Gelatin-Based Hydrogel Incorporated with Two-Dimensional Nanosheets for Multimodal Healing of Bacteria-Infected Wounds
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	wound healing, injectable hydrogel, MnO2 nanosheets, antibacterial, Fenton reaction, gas therapy, photothermal therapy
چکیده	The design and development of multifunctional injectable hydrogels with high photothermal antibacterial activity and shape adaptability to accelerate bacteria-infected wound healing is of critical importance in clinical applications. In this study, a hybrid hydrogel composed of gelatin, iron, and MnO2 nanosheets was prepared by multiple interactions, including coordinative and hydrogen bonding as well as electrostatic attraction. The introduced MnO2 and Fe components made the hydrogels photothermally and chemodynamically active, thereby endowing them with potent antibacterial capabilities against both Gram-negative and Grampositive bacteria. Because of the Fenton activity of the hydrogels, they could produce abandoned oxygen, which is highly crucial in the healing process of wounds. They also showed good cytocompatibility and hemocompatibility as well as high hemostatic properties. Moreover, the injectable hydrogels could fill irregular wounds and significantly accelerate bacteria-infected wound healing through decreasing the inflammatory response and increasing blood vessels. These features indicated the promising potential of the multifunctional hydrogel for healing infected full-thickness wounds.
پژوهشگران	بائولین گو (نفر ششم به بعد)، عزیز ملکی (نفر ششم به بعد)، ویرجیلو متتولی (نفر ششم به بعد)، ایکو هیراتا (نفر ششم به بعد)، عبدالله سلیمی (نفر ششم به بعد)، محمدعلی شهبازی (نفر ششم به بعد)، پویان مکوندی (نفر ششم به بعد)، هادی باقری (نفر پنجم)، وجیهه علی نژاد (نفر چهارم)، فخری حقی (نفر سوم)، علی کلانتری حصاری (نفر دوم)، شایسته بوچانی (نفر اول)