مشخصات پژوهش

عنوان	Synthesis of N-(4-Chlorobutanoyl)-1,2-Dihydro-(4H)-3,1-Benzoxazin-4-one Derivatives
نوع پژوهش	مقاله ارائه شده کنفرانسی
کلیدواژه‌ها	1,2-Dihydro-3,1-benzoxazin-4-ones, Antranilic acid, Schiff-base, 4-Chlorobutanoyl chloride.
چکیده	3,1-Benzoxazin-4-one and their derivatives1,2 are versatile intermediates in the synthesis of heterocycles with high pharmacological and biological activities.3,4 Here, we report a practical and convenient synthesis of N-(4-chlorobutanoyl)-1,2-dihydro-(4H)-3,1-benzoxazin-4-ones by cyclization reaction of Schiff-bases 3 (produced by condensation reaction of anthranilic acid derivatives 1 with benzaldehyde derivatives 2 at room temperature) with 4-chlorobutanoyl chloride at room temperature (Scheme 1). The presence of Cl in the end of butanoyl chain, makes the produced benzoxazine-4-ones 4 more reactive for further reactions against nucleophiles. The structures of all synthesized compounds were determined on the basis of their spectroscopic data.
پژوهشگران	جمال عزیزی (نفر دوم)، فرزاد نیک پور (نفر اول)