مشخصات پژوهش

عنوان	A Simple, Robust and Efficient Computational Method for Partition Coefficients of Substituted Aromatic Drugs
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	Computational Method , Partition Coefficients , Substituted Aromatic Drugs , n-Octanol/Water
چکیده	In this paper, multiple linear regression (MLR) was used to build quantitative structure property relationship (QSPR) of n-octanol-water partition coefficient (logPo/w) of 195 substituted aromatic drugs. The molecular descriptors were calculated for each compound by the VLifeMDS. By applying genetic algorithm/multiple linear regressions (GA/MLR) the most relevant descriptors were selected to build a QSPR model. The robustness of the model was characterized by the statistical validation and applicability domain (AD). The prediction results from MLR are in good agreement with the experimental values. The R2 and Q2 LOO for MLR are 0.9433, 0.9341. The AD of the model was analyzed based on the Williams plot. The effects of different selected descriptors are described.
پژوهشگران	امین رستمی (نفر سوم)، سعدی سعید پور (نفر دوم)، ئه سرین بهمنی (نفر اول)