مشخصات پژوهش

عنوان	Stability of astaxanthin-loaded nanostructured lipid carriers as affected by pH, ionic strength, heat treatment, simulated gastric juice and freeze-thawing
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	Nanostructured lipid carriers (NLCs), Astaxanthin, Physical stability, Delivery systems, Encapsulation, Functional foods
چکیده	Nanostructured lipid carriers (NLCs) offer many potential benefits for incorporating lipophilic molecules into clear/opaque food systems. In this study, the influence of pH, ionic strength, thermal treatment, simulated gastric juice (SGJ), and freeze-thawing on the stability of astaxanthin-loaded NLCs (Ax-NLCs) was examined. Ax-NLCs (containing α-tocopherol and ethylenediaminetetraacetic acid as antioxidants) were stabilized with Tween 80 and lecithin (≈94 nm), and studied for the above mentioned purpose. The size of Ax-NLCs increased at low pH values (≤ 5), high NaCl concentrations (≥ 50 mM), and slightly at SGJ, mainly because of decreasing the ζ-potential. Moreover, thermal treatment at 80/90 ˚C led to an increase in Ax-NLCs size. Glycerol was found as an appropriate cryoprotectant for preventing aggregation of Ax-NLCs during freeze-thawing. pH, ionic strength, heat and SGJ had no drastic effects on the chemical stability of astaxanthin in NLCs. These results have valuable implications for the utilization of food-grade NLCs.
پژوهشگران	فردین تمجیدی (نفر اول)، علی نصیرپور (نفر چهارم)، ژاله ورشوساز (نفر سوم)، محمد شاهدی (نفر دوم)