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چکیده
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The synthesis of optically active compounds such as pharmaceutical products, agrochemicals, fine chemicals, or synthetic intermediates, is one of the most fascinating aspects of modern organic synthesis. In this manner, most of the new drugs reaching the market today are single enantiomers, rather than the racemic mixtures that dominated up to ten years ago. Because of synthetic importance of enantiomerically pure molecules, in 2001 the Nobel Prize in Chemistry was awarded to William R. Knowles and Ryoji Noyori ‘‘for their work on chirally catalyzed hydrogenation reactions’’, and to K. Barry Sharpless ‘‘for his work on chirally catalyzed oxidation reactions’’. The various methods have employed for enantioselective synthesis of organic compounds which can be divided into four major classes: (1) substrate-controlled methods; (2) auxiliary-controlled methods; (3) reagent-controlled methods, and (4) catalyst-controlled methods. Racemate resolution and dynamic kinetic resolution also still remains important methods to obtain pure enantiomers. In this presentation, we have review applicability of our recent works in synthesis of some important enantiomerically pure molecules and in some typical asymmetric reactions by utilizing above mentioned methods.
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