مشخصات پژوهش

عنوان	Application of pyridyl Trost ligand in asymmetric allylic oxidation
نوع پژوهش	مقاله ارائه شده کنفرانسی
کلیدواژه‌ها	Kharasch–Sosnovsky reaction,enantiomeric excess,allylic oxidation, Trost ligand
چکیده	Asymmetric allylic oxidation of olefins with peresters in the presence of copper salts (known as the Kharasch–Sosnovsky reaction) is a significant transformation in asymmetric organic synthesis. Through this reaction, a new functional group (carboxyl) is formed and the olefinic double bond isn’t changed [1]. In the course of our studying on asymmetric synthesis, at first the optically active pyridyl Trost ligand was easily prepared from available starting material [2] and then, we utilized this ligand in asymmetric allylic oxidation of cyclic olefins under various conditions. The best yields (93%) and reasonable enantiomeric excess (35%) was obtained in low temperature (-10 °C) and in the solvent of acetonitile and in the presence of catalytic amount of copper (I) hexafluorophosphate (10%). Also it was further to note that adding a few drops more of phenylhydrazine reduced reaction time and increased ee% of desirable allylic esters.
پژوهشگران	خسرو جدیدی (نفر چهارم)، فربود صلاحی (نفر سوم)، سعدی صمدی (نفر دوم)، عبدالحمید آروین نژاد (نفر اول)