مشخصات پژوهش

عنوان	A Facile Synthesis of Novel Spiro[oxindole-isoxazolidine] drived from unreactive ketonitrone and various maleimides via 1,3-dipolar cycloaddition
نوع پژوهش	مقاله ارائه شده کنفرانسی
کلیدواژه‌ها	Spirooxindole, isatin,regioselective, cyclocondensation, ionic liquid
چکیده	Spiro compounds represent an important class of naturally occurring substances characterized by their highly pronounced biological properties [1]. The derivatives of Spirooxindole ring, spacially spiro [oxindole-isoxazolidine] find very wide biological application as antimicrobial, antitumour, anti HIV and antibiotic agents [2,3]. Due to the above reasons, In continuation of our ongoing research program on the synthesis of spiro heterocycles [4], herein we report for the firs time a regio and diastereoselective synthesis of a rare class of new spiro [indole-isoxazolidine] 3 in good yields from 1,3-dipolar cycloaddition of unactive isatin ketonitrone 1 and maleimides 2 under classical and solvent free conditions. Highly diastereo and regioselective cyclocondensation products were obtained under environmentally friendly ionic liquid conditions.
پژوهشگران	نعیمه شهرستانی (نفر چهارم)، خسرو جدیدی (نفر پنجم)، سعدی صمدی (نفر سوم)، پریسا اسلامی (نفر دوم)، لاله فرجی (نفر اول)