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چکیده
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A new survey shows that indolizidines and pyrrolizidines are very attractive synthetic targets because of their known interesting biological activity and their presence in a wide variety of natural products.[1] Since we have involved in the 1,3-dipolar cycloaddition reaction with isatinazomethine ylides 1 for several years, we decided to prepared some new indolizidines 7 and pyrrolizidines 6 by own way.were trapped by various dipolarophiles 3 and gave corresponding indoloindolizidines 4 and indolopyrrolizidines 5. Since the indolin ring in the spiro adducts is easily cleaved, the sequence of cycloaddition followed by ring cleavage of them and some of other series of similar derivatives that were on hand from our previous research (scheme 1). The structural assignments of the new attrective targets 6 and 7, that obtained bIn this work, at first, the reactive isatinazomethine ylides 1 and 2, generated in situ from the corresponding amino acidsy the above strategy, were determined by NMR spectra and analytical data
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