مشخصات پژوهش

عنوان	Synthesis of new enantiomerically pure spirooxindolopyrrolizidines via a three-component asymmetric 1,3-dipolar cycloaddition reaction of azomethine ylides derived from isatin
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	Chiral spirooxindolopyrrolizidines, Asymmetric 1,3-dipolar, Chiral auxiliaries, Azomethine ylide, Three-component reaction
چکیده	An efficient, one-pot, three-component procedure for the synthesis of a small library of new chiral spirooxindolopyrrolizidines with high regio-, diastereo-, and enantioselectivity, from the 1,3-dipolar cycloaddition of azomethine ylides and optically active cinnamoyl oxazolidinone is described. The process occurs at room temperature in aqueous ethanol as a green solvent and in the absence of any Lewis acids. The oxazolidinone chiral auxiliary is removed in a non-destructive manner. The reaction mechanism is discussed on the basis of the assignment of the absolute configuration of the cycloadducts, and on theoretical calculations.
پژوهشگران	محمد جواد تقی زاده (نفر اول)، عبدالحمید آروین نژاد (نفر دوم)، سعدی صمدی (نفر سوم)، خسرو جدیدی (نفر چهارم)، عبدالله جاویدان (نفر پنجم)، بهروز نوتاش (نفر ششم به بعد)