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چکیده
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Magnetic nanoparticle-based materials (MNPs) are ideal supports for the immobilization of catalysts, since they can be recollected by using an external magnet [1]. As an alternative reagent or catalyst to the toxic liquid bromine, a wide variety of organic ammonium tribromides (OATBs) were designed [2]. However, recoverability and reusability of OTBs catalysts are high challenge for their application in organic reactions. Quinazolinones are very important building blocks found inbiologically and pharmacologically active compounds, natural products, and functional materials.One conventional method for the preparationof quinazolinones is oxidative cyclization of Schiff bases derivedfrom o-aminobenzamidesand aldehydes in the presence of oxidants[3].Although these protocols represent considerable progress, however, the recovery and reusability of the catalyst remains a major problem with reported method. Very recently we reported the application of DABCO tribromide supported on magnetic nanoparticles(MNPs-DABCO tribromide)as a magnetically nanocatalyst for the oxidation of sulfide[4], herein, the catalytic activity of MNPs-DABCO tribromide was investigated in the synthesis ofquinazolinones from the oxidative cyclization of oaminobenzamidesand aldehydes using H2O2 in EtOH.
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