مشخصات پژوهش

عنوان	Processing of the dynamin Msp1p in S. pombe reveals an evolutionary switch between its orthologs Mgm1p in S. cerevisiae and OPA1 in mammals
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	Mitochondrial dynamics Mitochondrial proteases Mitochondria Msp1p Mgm1p OPA1
چکیده	Mitochondrial fusion depends on the evolutionary conserved dynamin, OPA1/Mgm1p/Msp1p, whose activity is controlled by proteolytic processing. Since processing diverges between Mgm1p (Saccharomyces cerevisiae) and OPA1 (mammals), we explored this process in another model, Msp1p in Schizosaccharomyces pombe. Generation of the short isoform of Msp1p neither results from the maturation of the long isoform nor correlates with mitochondrial ATP levels. Msp1p is processed by rhomboid and a protease of the matrix ATPase associated with various cellular activities (m-AAA) family. The former is involved in the generation of short Msp1p and the latter in the stability of long Msp1p. These results reveal that Msp1p processing may represent an evolutionary switch between Mgm1p and OPA1.
پژوهشگران	پاسکال بلنگور (نفر ششم به بعد)، لورن ج. امورین (نفر ششم به بعد)، سیندی کاولیر (نفر ششم به بعد)، لاتیا آرنئون پلوکیون (نفر پنجم)، مرلین دالویا (نفر چهارم)، آلن دیوت (نفر سوم)، اینگرید لروی (نفر اول)، فرنوش خسروبخش (نفر دوم)