مشخصات پژوهش

عنوان	Synthesis of 3-Pyrroline-5-ones in α-Pinene
نوع پژوهش	مقاله ارائه شده کنفرانسی
کلیدواژه‌ها	3-Pyrroline-5-ones, α-Pinen, dialkyl acetylenedicarboxylates, triphenylphosphine
چکیده	N-substituted 3-pyrrolines are an important class of compounds with exhibit biological activities [1] and serve as useful synthetic intermediates [2]. There are also many examples of pyrroline containing natural products with interesting pharmacological activities [3]. We previously reported synthesis of 3-pyrroline-5-one derivatives by the three component reaction of ethyl 2-arylamino-2-oxoacetates and dialkyl acetylenedicarboxylates in the presence of triphenylphosphine [4, 5]. We wish to report here reaction between achiral and chiral ethyl 2-arylamino-2-oxoacetates and dialkyl acetylenedicarboxylates in the presence of triphenylphosphine in α-Pinene. The results show no enantioselectivity or diastereoselectivity when the reactions carried out in this solvent.
پژوهشگران	مرتضی بیدار (نفر چهارم)، کوروش پوردوایی (نفر سوم)، فاطمه ناظم (نفر دوم)، فاروق نصیری (نفر اول)