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چکیده
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Interactive effects of exercise and anti- oxidant supplements are still not well known. So, The aim of this study was to investigate the effects of high intensity interval training (HIIT) and vita- min E (VE) on the PI3K/NRF2 pathway in the hip- pocampus of Alzheimer’s disease rats (AD). In this expremantal study, fifty aged AD rats with 10 mg/ kg trimethyltin (TMT), were divided into groups 1) TMT, 2) VE solvent (Sham), 3) VE (30 mg/kg), 4) HIIT (90-95% of the maximum running speed) and 5) HIIT+VE. Ten healthy rats were included in the healthy control group to investigate the effect of TMT on research variables. Results Showed that, HIIT, VE and HIIT+VE decreased amyloid beta (P≤0.05), HIIT and HIIT+VE decreased NF-kB (P≤0.05) as well as HIIT, VE and HIIT+VE increased SOD and decreased MDA. HIIT simultaneously with VE increased PI3K, NRF2, and Cat. HIIT, VE and the interaction of HIIT and VE decreased the expression of miR-125b and increased expression of miR-132 (P≤0.05); The combination of HIIT and VE increased capillary density in areas 1 and 3, the percentage of healthy cells in C1 and C3 areas of the hippocam- pus (P≤0.05). The effects of HIIT and HIIT+VE on improving memory were better than VE (P≤0.05). It seems that HIIT and VE can synergistically increase the expression of antioxidant genes from the PI3K/ NRF2 pathway by decreasing miR-125 and increasing miR-132. Probably, this happens by reducing some AD markers, increasing angiogenesis and cell protec- tion as well as cognitive memory in AD situation.
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