مشخصات پژوهش

عنوان	Anti-neoplastic Effects of Juglans Regia L. Green Fruit Pericarp on Breast Cancer Cell Lines
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	Breast Cancer Cell Lines, Cytotoxicity, Juglans Regia L. Green, Fruit Pericarp, Methanol Extract
چکیده	Background: Recently, more attention has been paid to the use of complementary medicine in breast cancer (BC) treatment.Juglans green fruit pericarp was found to have anti-cancer characteristics. Objectives: We aimed here to assess the possible anti-proliferative effects of methanolic extract of Juglans green fruit pericarpin BC cell lines.Methods: MCF-7 and MDA-MB-231 cells were examined with different concentrations of Juglans green fruit pericarp extract. Thecell viability was investigated using a 3 - 2, 5-diphenyl tetrazolium bromide (MTT) assay. Also, different phases of the cell cyclewere analyzed utilizing a flow cytometry method. Finally, the ability of cancer cells to create colonies was studied post-treatment with Juglans green fruit pericarp.Results: Our findings showed that the methanol extract has substantial cytotoxicity on MCF-7 and MDA-MB-231 cell lines. Wealso observed a significant arrest in the G0/G1 phase in cancer cells post-treatment with the methanol extract.Conclusions: In summary, our results introduced a cytotoxic property for Juglans green fruit pericarp methanol extract for MCF-7 and MDA-MB-231 cell lines. Future studies are needed to further evaluate its utility as a potential complementary therapy for BC
پژوهشگران	السا میرزاد (نفر اول)، میترا جوانمردی (نفر دوم)، مسعود حیدری زاده (نفر سوم)، محمد عبدی (نفر چهارم)