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چکیده
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Magnetic drug targeting (MDT) has garnered significant attention in the field of cancer treatment and other diseases due to its ability to minimize side effects and enhance treatment efficacy. This approach involves the injection of magnetic nanoparticles into the bloodstream, which are then guided to the tumor site through the application of an external magnetic field. In this particular study, the researchers focused on investigating the impact of various factors on the absorption of nanoparticles downstream of a stenosis in a vessel with local symmetric stenosis. Specifically, they examined the effects of the nanoparticles’ diameter, Reynolds number, the Newtonian and non-Newtonian behavior of blood, magnetic field strength, and the type of magnetic field source. The two types of magnetic field sources considered were a current-carrying wire and a permanent magnet. The findings revealed that an increase in the nanoparticles’ diameter and the magnetic field’s strength led to an increase in the number of captured nanoparticles. Conversely, an increase in the Reynolds number resulted in a decrease in the captured nanoparticles. Additionally, the study highlighted the importance of considering blood as a non-Newtonian fluid for blood velocities lower than 60 mm/s (i.e., in arteries with a diameter lower than 2 mm). Furthermore, when comparing the efficiency of different magnetic fields, it was observed that the current-carrying wire was more effective for small-sized vessels with stenosis.
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