عنوان	Synthesis of Novel 4H-Chromenes Containing a Pyrimidine-2-Thione Function in the Presence of Fe3O4 Magnetic Nanoparticles and Study of Their Antioxidant Activity
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	Fe3O4 nanoparticles; antioxidant; synthesis; cytotoxic activity; chromenopyrimidinethiones
چکیده	The aim of the present work was to search for identification of novel reactive oxygen species (ROS) scavengers by testing new fused chromenopyrimidinethiones, which was synthesized using Fe3O4 nanoparticles. The new compounds were also tested for their cytotoxic activity. The obtained results showed that the incorporated pyrimidinethione moiety significantly increase antioxidant activity. In conclusion, the study of the pharmacological properties of the new chromenopyrimidinethiones allowed establishing new structure–activity relationships for splitting antioxidant and cytotoxic activity of these compounds.
پژوهشگران	مهدی خوبی (نفر اول)، علی رمضانی (نفر دوم)، زهرا حجتی (نفر سوم)، راحله شاکری (نفر چهارم)، مهدی خوشنویس زاده (نفر پنجم)، سنگ وو جو (نفر ششم به بعد)، سوسن کبودانیان اردستانی (نفر ششم به بعد)، علیرضا فرومدی (نفر ششم به بعد)، عباس شفیعی (نفر ششم به بعد)