مشخصات پژوهش

عنوان	On the design of human immunodeficiency virus treatment based on a non-linear time-delay model
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	HIV, HAART, Optimal Control, ESDRE, NDDE
چکیده	Mathematical modelling and methods from control theory can be employed to find appropriate drug regimens in human immunodeficiency virus (HIV) treatment. In this study, using a non-linear time-delay model, the authors design some suboptimal highly active antiretroviral therapy (HAART) [http://www.en.wikipedia.org/wiki/Protease_inhibitor_%28pharmacology%29] regimens for patients with HIV. The non-linear delayed model is used to describe the dynamical interactions between HIV and human immune system in the presence of HAART. Based on the model, a set point tracking problem is defined in order to set the number of susceptible CD4+T cells to a desired value. To solve this set point tracking problem in a suboptimal way, the authors introduce a new method which is able to consider constraints on the amount of drug dosage. It is proved that the proposed method is able to set the number of susceptible CD4+T cells to the desired value. Simulation results confirm that the method is efficient even in the presence of parametric uncertainties.
پژوهشگران	حمید خالوزاده (نفر دوم)، یزدان باتمانی (نفر اول)