عنوان	Detection of Mouse Cytomegalovirus in Adenocarcinoma Bearing Razi/A Mice: Molecular and Pathological Studies
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	Mouse Cytomegalovirus, Breast Cancer, Human cytomegalovirus, MCK-2 Gene
چکیده	Despite a lot of research, the etiology and progression of breast cancer remain incompletely understood. Recently, human cytomegalovirus (HCMV) was reported as a risk factor for breast cancer. The aim of this study was to know whether breast cancer could be caused by cytomegalovirus or not? In this experiment seventeen samples of RAZI/A mice with spontaneous breast cancer were being gathered from laboratory animals department. Histopathology and polymerase chain reaction (PCR) tests were done on breast tissue samples. Formalin-fixed tissue specimens were obtained from mouse normal breast tissues (n:17) and mouse mammary tumors (n:17). Detection of mouse cytomegalovirus was done by the pUC57-MCK-2 plasmid. Our histopathology data showed Adenocarcinoma type B in mouse with mammary tumors. There was a significant difference between mice with spontaneous breast cancer and control by Pearson Chi-Square (Value: 17.000b and P=0.000). More research will be needed to determine the effect of cytomegalovirus on breast cancer.
پژوهشگران	فاطمه عابدینی (نفر اول)، مجتبی محرمی (نفر دوم)، پگاه شمس (نفر سوم)، محمد اسلام پناه (نفر چهارم)، حمیده عادلدوست (نفر پنجم)، اسعد وزیری (نفر ششم به بعد)، فاطمه طالب لو (نفر ششم به بعد)، محمد ابراهیمی (نفر ششم به بعد)