عنوان	Stereoselective synthesis of dialkyl 3-spiroindanedione-1,2,3,3atetrahydropyrrolo[ 1,2-a]quinoline-1,2-dicarboxylates
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	Quinoline; 4-Methylpyridine; N-Methylimidazole; Acetylenic esters; Spiro compound; 1,3-Indanedione The quinoline moiety is present as a substructure in a broad range of biologically active compounds, most notably within anti-malaria agents.1 Due to their biological importance, quinoline derivatives such as pyrroloquinolines have become synthetic targets of many organic and medicinal chemists.
چکیده	The 1:1 intermediate generated by the addition of quinoline to dialkyl acetylenedicarboxylates is trapped by 1,3-indanedione to yield dialkyl 3-spiroindanedione-1,2,3,3a-tetrahydropyrrolo[1,2-a]quinoline-1,2-dicarboxylates in good yields. The structures of these products were confirmed by NMR and single-crystal X-ray diffraction studies
پژوهشگران	عیسی یاوری (نفر اول)، انور میرزائی (نفر دوم)، لقمان مرادی (نفر سوم)، نرگس حسینی (نفر چهارم)