مشخصات پژوهش

عنوان	Synthesis of Fluorinated Dialkyl 1-Aryl-4-alkoxy-5-oxo-2,5-dihydro-1H-pyrrole-2,3-dicarboxylates
نوع پژوهش	مقاله ارائه شده کنفرانسی
کلیدواژه‌ها	dialkyl acetylenedicarboxylates, triphenylphosphine, atropisomerism
چکیده	Five memberd ring lactams have successfully been used in routes to various alkaloids and are suitable precursors for unusual y-amino acids such as statine and its analogues. There are also many examples of pyrroline-containing natural products with Interesting pharmacological activates. Typical examples are the antitumor alkaloide Jatropham and the platelet aggregation inhibitor PI- 091. As part of our current studies on the development of new routes to heterocyclic and carbocyclic systems [1] we now report a simple one-pet synthesis of’ highly fictionalized 3-pyrrolin- 5-ones 3. Thus. reaction of dialkyl acetylenedicarboxylates 1 with alkyl 2-arylamino-2-oxo-acetates 2 in the presence of triphenylphosphine leads to the corresponding dialkyl 1 -aryl-4-alkoxy-5-oxo- 2.5-dihydro-1H- pyrrole-2,3-dicarboxylates 3a-3g in good yields (Scheme 1).
پژوهشگران	حوریه جهانیانی (نفر سوم)، عیسی یاوری (نفر دوم)، فاروق نصیری (نفر اول)