The aim of this research was to explore the effect of flipped classroom on English as a Foreign Language (EFL) learners’ reading skill and reading anxiety. For this purpose, a sample of 44 Iranian EFL learners was recruited and randomly assigned to a flipped group (N =23) and a non-flipped group (N =21). Using a quasi-experimental design, the researchers employed an experimental group that received flipped instruction and a control group that were instructed based on the regular method for a period of four months. The reading component of the Cambridge Preliminary English Test (CPET) and a scale of reading anxiety were given to assess the reading comprehension and reading anxiety of the participants as pre-test and post-test of the study. The outcomes of the research indicated that the learners in the flipped class substantially performed better than those of the nonflipped class regarding EFL reading gains. Also, flipping the course significantly reduced reading anxiety of the participants. According to these results, it may be concluded that EFL teachers can utilize flipped instruction for their reading courses.