Flooding is one of the most significant environmental challenges and can easily cause fatal incidents and economic losses. Flood reduction is costly and time-consuming task; so it is necessary to accurately detect flood susceptible areas. This work presents an effective flood susceptibility mapping framework by involving an adaptive neuro-fuzzy inference system (ANFIS) with two metaheuristic methods of biogeography based optimization (BBO) and imperialistic competitive algorithm (ICA). A total of 13 flood influencing factors, including slope, altitude, aspect, curvature, topographic wetness index, stream power index, sediment transport index, distance to river, landuse, normalized difference vegetation index, lithology, rainfall and soil type, were used in the proposed framework for spatial modeling and Dingnan County in China was selected for the application of the proposed methods due to data availability. There are 115 flood occurrences in the study area which were randomly separated into training (70% of the total) and verification (30%) sets. To perform the proposed framework, the step-wise weight assessment ratio analysis algorithm is first used to evaluate the correlation between influencing factors and floods. Then, two ensemble methods of ANFIS-BBO and ANFIS-ICA are constructed for spatial prediction and producing flood susceptibility maps. Finally, these resultant maps are assessed in terms of several statistical and error measures, including receiver operating characteristic (ROC) curve and area under the ROC curve (AUC), root-mean-square error (RMSE). The experimental results demonstrated that the two ensemble methods were more effective than ANFIS in the study area. For instance, the predictive AUC values of 0.8407, 0.9045 and 0.9044 were achieved by the methods of ANFIS, ANFIS-BBO and ANFIS-ICA, respectively. Moreover, the RMSE values for ANFIS, ANFIS-BBO and ANFIS-ICA using the verification set were 0.3100, 0.2730 and 0.2700, respectively. In addition, as regards ANFIS-BBO and ANFIS-ICA, a total areas of 39.30% and 35.39% were classified as highly susceptible to flooding. Therefore, the proposed ensemble framework can be used for flood susceptibility mapping in other sites with similar geo-environmental characteristics for taking measures to manage and prevent flood damages.