This study presents three new hybrid artificial intelligence optimization models—namely, adaptive neuro-fuzzy inference system (ANFIS) with cultural (ANFIS-CA), bees (ANFIS-BA), and invasive weed optimization (ANFIS-IWO) algorithms—for flood susceptibility mapping (FSM) in the Haraz watershed, Iran. Ten continuous and categorical flood conditioning factors were chosen based on the 201 flood locations, including topographic wetness index (TWI), river density, stream power index (SPI), curvature, distance from river, lithology, elevation, ground slope, land use, and rainfall. The step-wise weight assessment ratio analysis (SWARA) model was adopted for the assessment of relationship between flood locations and conditioning factors. The ANFIS model, based on SWARA weights, was employed for providing FSMs with three optimization models to enhance the accuracy of prediction. To evaluate the model performance and prediction capability, root-mean-square error (RMSE) and receiver operating characteristic (ROC) curve (area under the ROC (AUROC)) were used. Results showed that ANFIS-IWO with lower RMSE (0.359) had a better performance, while ANFIS-BA with higher AUROC (94.4%) showed a better prediction capability, followed by ANFIS0-IWO (0.939) and ANFIS-CA (0.921). These models can be suggested for FSM in similar climatic and physiographic areas for developing measures to mitigate flood damages and to sustainably manage floodplains.