Dust storms are believed to play an essential role in many climatological, geochemical, and environmental processes. This atmospheric phenomenon can have a significant negative impact on public health and significantly disturb natural ecosystems. Identifying dust-source areas is thus a fundamental task to control the effects of this hazard. This study is the first attempt to identify dust source areas using hybridized machine-learning algorithms. Each hybridized model, designed as an intelligent system, consists of an adaptive neuro-fuzzy inference system (ANFIS), integrated with a combination of metaheuristic optimization algorithms: the bat algorithm (BA), cultural algorithm (CA), and differential evolution (DE). The data acquired from two key sources – the Moderate Resolution Imaging Spectroradiometer (MODIS) Deep Blue and the Ozone Monitoring Instrument (OMI) – are incorporated into the hybridized model, along with relevant data from field surveys and dust samples. Goodness-of-fit analyses are performed to evaluate the predictive capability of the hybridized models using different statistical criteria, including the true skill statistic (TSS) and the area under the receiver operating characteristic curve (AUC). The results demonstrate that the hybridized ANFIS-DE model (with AUC = 84.1%, TSS = 0.73) outperforms the other comparative hybridized models tailored for dust-storm prediction. The results provide evidence that the hybridized ANFIS-DE model should be explored as a promising, cost-effective method for efficiently identifying the dust-source areas, with benefits for both public health and natural environments where excessive dust presents significant challenges.