اکرم آشوری

The development of new procedures and efficient synthesis of biological molecules are necessary and inevitable in chemistry, pharmacology and biology. Thiadiazole derivatives which have several heteroatoms in their original structure are known as one of the important functional groups in heterocyclic chemistry but the synthesis of these compounds are included methods with multistage reaction conditions that somehow turned too hard. Among the modern synthesis methods, the use of nanocatalyst to facilitate and accelerate the synthetic routes should be noted. As the biological activities of symmetrical thiadiazoles were known1, in this work we tried to use the nanoparticles as catalyst to resolve this matter and obtain mild and green reaction condition. We have prepared symmetrical thiadiazoles using dithiocarbamate derivatines and hydrazine sulfate in water under reflux condition.The desired thiadiazole rings were obtained in high yields.