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Title
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A simple and expedient method for the stepwise synthesis of 2-ethoxy-(4H)-3,1-benzoxazine-4-ones
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Type
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JournalPaper
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Keywords
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2-Ethoxy-(4H)-3,1-benzoxazine-4-ones, Diethyl dicarbonate, Cyanuric chloride, N,N'-Dicyclohexylcarbodiimide, Dehydrocyclization reagent
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Abstract
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A simple and practical route is described for the synthesis of 2-ethoxy-(4H)-3,1-benzoxazine-4-ones using the coupling reaction of anthranilic acid derivatives with diethyl dicarbonate following with fast cyclization of the carbamate adduct with a dehydrocyclization agent such as cyanuric chloride and N,N'-dicyclohexylcarbodiimide in PEG at room temperature. High yields of the products obtained under mild reaction conditions with simple work-up of the reaction mixture.
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Researchers
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Mahnaz Sharafi (Third Researcher), bahmani asrin (Second Researcher), Farzad Nikpour (First Researcher)
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