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Title
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p-Toluenesulfonyl Chloride (p-TsCl)-Catalyzed Trimethylsilylation of Hydroxyl Groups Using Hexamethyldisilazane and Their Regeneration Under Mild Conditions: The First Example for Catalytic Application of p-Toluenesulfonyl Chloride
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Type
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JournalPaper
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Keywords
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Hexamethyldisilazane; hydroxyl group; p-toluenesulfonyl chloride; trimethylsilylation
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Abstract
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The first catalytic application of p-toluenesulfonyl chloride (p-TsCl) for the efficient and selective trimethylsilylation of various types of hydroxyl groups with hexamethyldisilazane (HMDS) in dichloromethane and desilylation of these compounds in water is reported. The reactions were carried out at room temperature and were found to proceed in good to excellent yields.
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Researchers
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Fatemeh Mantashlo (Third Researcher), Amin Rostami (Second Researcher), Ardeshir Khazaei (First Researcher)
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