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Title
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Synthesis of 2-aryl-1-(phenylsulfonyl)-1,2-dihydrobenzo-3,1-oxazine-4(1H)-one and 2-aryl-1-(phenylsulfonyl)-2,3-dihydroquinazoline-4(1H)-one
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Type
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Presentation
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Keywords
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Schiff-base, 1,2-dihydro-(4H)-3,1-benzoxazin-4-ones,benzenesulfonyl chloride, quinazoline-4-ones, 1,2-dihydro-(4H)-quinazoline-4-ones
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Abstract
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There are very few synthetic routes for the synthesis of N-substituted-1,2-dihydro-(4H)-3,1-benzoxazin-4-ones and 1-substituted-1,2-dihydro-(4H)-quinazoline-4-ones [1,2]. They are good potential starting materials for synthesis of pharmaceutical and biological important heterocycles [3,4]. The Schiff-bases produced from the condensation reaction of aryl aldehydes with anthranilic acid or anthranilamide, are cyclized with benzenesulfonyl chloride to produce the 1,2-dihydro-(4H)-3,1-benzoxazin-4-ones2and 1,2-dihydro-(4H)- quinazoline-4-ones 4respectively in PEG as a green solvent (Scheme 1). Good to high yield of the products are obtained under mild reactions conditions with simple work-up.
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Researchers
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Farzad Nikpour (First Researcher), Sara Zandi (Second Researcher)
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