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Title
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Extending time profile of morphine-induced analgesia using a chitosan-based molecular imprinted polymer nanogel
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Type
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JournalPaper
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Keywords
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Molecular imprinted polymer, Morphine analgesia, Controlled release, Chitosan, Mice
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Abstract
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Chitosan-based molecular imprinted polymer (CS-MIP) nanogel is prepared in the presence of morphine template, fully characterized and used as a new vehicle to extend duration of morphine analgesic effect in Naval Medical Research Institute mice. The CS-MIP nanogel with ≈25 nm size range exhibits 98% loading efficiency, and in vitro release studies show an initial burst followed by an extended slow release of morphine. In order to study the feasibility of CS-MIP nanogel as morphine carrier, 20 mice are divided into two groups randomly and received subcutaneous injection of morphine-loaded CS-MIP and morphine (10 mg kg−1) dissolved in physiologic saline. Those received injection of morphine-loaded CS-MIP show slower and long lasting release of morphine with 193 min effective time of 50% (ET50) analgesia compared to 120 min ET50 in mice received morphine dissolved in physiologic saline. These results suggest that CS-MIP nanogel can be a possible strategy as morphine carrier for controlled release and extension of its analgesic efficacy.
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Researchers
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Shamseddin Ahmadi (Third Researcher), Mousa Ghaemy (Second Researcher), Marjan Hassanzadeh (First Researcher)
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