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Title
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1,3Dipolar Cycloaddition of Azomethine Ylides :A Facile Synthesis of Novel Spiro Indolizidines
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Type
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Presentation
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Keywords
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hydroindolizidines, spiro hydroindolizidine,pipecolinic acid
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Abstract
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1,3Dipolar cycloaddition of azomethine ylides with olefins are one of the most important reactions in organic synthesis since it produces a variety of five-membered heterocycles, such as hydroindolizidines with highly diastereoselective and regioselective. A new survey shows indolizidines are very attractive synthetic targets due to their interesting biological activity as well as their presence in a wide variety of natural products [1,2]. Despite of their interesting and potential increased biological activities and their presence in a wide variety of natural products, a few attention has have been given to development and synthesis of spiro hydroindolizidine compounds. Due to the above reasons, and as a part of our ongoing research program on the synthesis of spiro heterocycles [3], we have developed for the first time a synthetic route for producing a novel class of spiro indolizidines 4. The reactions were carried out under four different conditions in a single pot three-component cyclocondensation of acenaphthenequinone 1, pipecolinic acid 2 and maleimides 3.
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Researchers
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Saadi Samadi (First Researcher), Khosrow Jadidi (Fifth Researcher), Parisa Eslami (Fourth Researcher), Hamid Arvinnezhad (Third Researcher), Laleh Faraji (Second Researcher)
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