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Title
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Synthesis of new chiral C1- and C2-symmetric ligands and application of them in some asymmetric reactions
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Type
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Presentation
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Keywords
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enantiomeric excess, chiral C2-symmetric,Mukaiyama- Michael Addition, immobilized, MCM-41
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Abstract
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In this research, we first synthesized chiral C2-symmetric oxazoline-based ligands, such as chiral C2-symmetric 2,2′ bisoxazoline (1), aza bisoxazoline (2) and chiral C1-symmetric amines (3) in high yield and enantiomeric excess. , then generated the chiral complex metal of them and investigated their reactivity these chiral complexes 1-3 as homogenous catalysis in some asymmetric reactions such as Asymmetric Mukaiyama- Michael Addition (Scheme 1). Another major goal of this study was immobilizing some of the synthesized ligands on MCM-41 in a systematic approach (Scheme 2) and application of these heterogeneous catalysis in above mention asymmetric organic reactions. Furthermore, we explained various factors that affect enantioselectivity in these reactions by our working model.
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Researchers
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Saber Nazari (Fifth Researcher), Laleh Faraji (Fourth Researcher), Hamid Arvinnezhad (Third Researcher), Saadi Samadi (Second Researcher), Khosrow Jadidi (First Researcher)
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