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Title
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Highly Regioselective and Diastereoselective, One-Pot, Four-Component Synthesis of Novel Spiroindenoquinoxalineindolizidine Derivatives
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Type
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JournalPaper
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Keywords
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spiroindenoquinoxalineindolizidines,Highly Regioselective, Diastereoselective,stereochemistry, 1,3-dipolar cycloaddition, azomethine ylides
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Abstract
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A one-pot, four-component procedure for the synthesis of novel spiroindenoquinoxalineindolizidines with high regioselectivity and diastereoselectivity from the 1,3-dipolar cycloaddition of azomethine ylides, generated from indenoquinoxalines and pipecolinic acid, and chalcones is described. The reaction occurs under reflux of ethanol as a green solvent and in the absence of any catalyst. The cycloadducts are obtained purely without future purification. The regiochemistry and stereochemistry of resultant cycloadducts have been determined by several 2D-NMR spectroscopic techniques and X-ray single crystal diffraction.
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Researchers
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Saadi Samadi (Third Researcher), Behrouz Notash (Not In First Six Researchers), Khosrow Jadidi (Fifth Researcher), Farbod Salahi (Fourth Researcher), Hamid Arvinnezhad (Second Researcher), Mehdi Moemeni (First Researcher)
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