A series of novel organosoluble polyamides (PAs) bearing different functional groups such as flexible ether, substituted imidazole, and xanthene rings and electron-withdrawing CF3 groups were synthesized from diamines and various dicarboxylic acids. The structures of diamines and PAs were fully characterized by elemental analysis, Fourier transform infrared spectroscopy, and proton nuclear magnetic resonance spectroscopy. The PAs showed good solubility in aprotic and polar organic solvents, with high thermal stability exhibiting the glass transition temperatures (Tgs) and 10% weight loss temperatures (T10%) in the range of 184–277°C and 410–480°C in N2 atmosphere, respectively. These polymers showed fluorescence emission upon irradiation with UV light. Diamine compounds and two of synthesized polymers were also screened for antibacterial activity against gram-positive and gram-negative bacteria, and the obtained results for all four combinations showed good inhibition. Extraction capability for heavy metal ions such as Cr3þ, Pb2þ, Hg2þ, Cd2þ, and Co2þ from aqueous solutions was also tested at 25°C and pH 7–8.