This article is analyzing Rene Descartes' philosophy, his ideas about the Subject, knowledge and cognition in the significant play, Endgame, by Samuel Beckett. Descartes' philosophy begins with a meditation on the individual and reaches the analysis of the relationship between mind and body. An analysis of Beckett's works in general and the Endgame in particular, reveals that Beckett has tried to represent such a philosophy in a particular way. Beckett approaches Enlightenment in general and Cartesian philosophy in particular satirically and points to the defects, gaps and the irresolvable dilemmas of the Cartesian philosophy.