This study attempts to shed light on the effects of ICTs on urban spatial structure through a systematic literature review by exploring the relationship between ICTs and the factors that shape this structure. Four scientific databases covering a period from 2000 to 2018 were searched for related literature using a vast variety of keywords. As a result, 130 articles were selected for this literature review. After studying these articles, their main findings were extracted and their major results were categorized based on a conceptual model. This model addresses the relationship between ICTs and four aspects of urban spatial structure: (a) spatial and physical aspects, (b) human aspects, (c) mobility and flows, and (d) activities (i.e., work, shopping, leisure). Generally, it can be concluded that ICTs have significant effects on the elements that shape urban spatial structure, and they can play a significant role in transforming this structure in the future.