1,3Dipolar cycloaddition of azomethine ylides with olefins are one of the most important reactions in organic synthesis since it produces a variety of five-membered heterocycles, such as hydroindolizidines with highly diastereoselective and regioselective. A new survey shows indolizidines are very attractive synthetic targets due to their interesting biological activity as well as their presence in a wide variety of natural products [1,2]. Despite of their interesting and potential increased biological activities and their presence in a wide variety of natural products, a few attention has have been given to development and synthesis of spiro hydroindolizidine compounds. Due to the above reasons, and as a part of our ongoing research program on the synthesis of spiro heterocycles [3], we have developed for the first time a synthetic route for producing a novel class of spiro indolizidines 4. The reactions were carried out under four different conditions in a single pot three-component cyclocondensation of acenaphthenequinone 1, pipecolinic acid 2 and maleimides 3.
