Potassium channels represent the largest family of ion channels. Among different types of K+ channels, KATP channels are involved in several physiological functions. Several studies suggested that KATP channels are involved in the central nervous system and in the peripheral actions of morphine. Previou studies have indicated that morphine shows state-dependent learning in passive avoidance task. The results of previous studies also support the hypothesis that the action of morphine on μ-opioid receptors is at least partly KATP channel-dependent. We have studied the effect of I.C.V. administration of naloxone and KATP channel modulators (glibenclamide and diazoxide) on the test day on restoration of memory by morphine in mice. The effect of scopolamine on restoration of memory on the test-day by glibenclamide was studied as well.
