Summary Objectives This study investigated the effect of resistance exercises (RE) with different volumes on appetite, its hormonal regulators (PYY and insulin), and plasma lipoprotein in overweight men. Methods Nine healthy overweight male students (age: 20.88 ± 2.52 years, weight: 99.53 ± 14.46 kg, body mass index: 29.7 ± 2.74 kg/m2) selected randomly and performed two RE protocols with high volume (5 sets × 12 repetitions at 75% of 12RM) and low volume (3 sets × 12 repetitions at 75% of 12RM load), in two randomized separate sessions. Blood samples were collected pre-exercise, immediately after, 1, 3, and 6 h after resistance exercise sessions. Results Plasma PYY concentrations significantly increased after both RE protocols. Also, plasma insulin concentrations were significantly increased in both protocols at 1 h after exercise compared to pre-exercise, 3 and 6 h post-exercise. Appetite suppression at the end of RE with high volume was higher than RE with low volume. Appetite measure was significantly lower immediately post-RE protocols at 1, 3 and 6 h post-exercise. Plasma HDL-C level increased significantly after resistance exercise. Conclusion Appetite suppression after resistance exercise that was observed in the present study may be due to increases in anorexigenic hormones such as PYY and insulin. Also, resistance exercise increased HDL-C levels that have protective effect against plaques generation.
