The flow characteristic is an important factor for many systems, like fine chemicals, pharmaceuticals, and crystallization. In this study, a 3D Computational Fluid Dynamics (CFD) model was done for analyzing flow characteristics in three coiled flow inverters and a helically coiled channel. The laminar Finite-Rate model was used to develop the model. The effects of Reynolds number (Re) and geometries on the flow characteristic were studied. The friction factor of various shapes was evaluated using the CFD model. The major objective of this study is to demonstrate the effects of geometry on pressure drop and friction factor as a flow characteristic from the fluid dynamics point of view. Results show that the coiled flow inverters have an important influence on mixing performance at various Reynolds numbers. The results show that the friction factor increased as the number of 90˚ bends increased. In addition, the friction factor of the coiled flow inverters is significantly higher than the helically coiled channel.