Advance knowledge of solar radiation is highly essential for multiple energy devotions such as sustainability in energy production and development of solar energy system. The current research investigates the capability of four data mining computation models, namely random forest (RF), random tree, reduced error pruning trees and hybrid model of random committee with random tree reduce (RC) for predicting daily measured solar radiation at four locations of Burkina Faso, i.e., Bur Dedougou, Bobo-Dioulasso, Fada-Ngourma and Ouahigouya. Daily data of seven climatic variables, namely maximum and minimum air temperature, maximum and minimum relative humidity, wind speed, evaporation and vapor pressure deficit, for the period 1998–2012 are used for solar radiation prediction. Different combinations of input variables are used according to correlation coefficient between the predictors and predictand, and the best input combination is selected based on the sensitivity of model output measured in terms of statistical indices. The obtained results are found consistence for all the meteorological stations. The highest accuracy in prediction is found when all the climate variables are used as input. The RC and RF showed the minimal absolute error in prediction at all the stations. The RMSE and NSE are found in the range of 0.03–0.05 and 0.77–0.91 for RC and 0.03–0.05 and 0.78–0.92 for RF at different stations. The results indicate that the proposed data mining models can be used for accurate prediction of solar radiation over the Burkina Faso.