Abstract Introduction: The present study investigates the early maladaptive schema in marital relationship as predictive of divorce in Isfahan. Method: The sample includes 150 divorce applicant couples and 155 ordinal couples (totally 620). Group of divorce applicants and court clients are used to select the divorce sample and random multi-staged sample taking method is used to select the control group. All sample couples were tested by Early Maladaptive Schema Scale (EMSs). Result: In spite of the descriptive statistic method, the discriminate analysis method was applied to analyse the data in this research. The results of the research approved the hypothesis of the research and demonstrated that divorce may be predicted based on early maladaptive schema. Discussion: the results derived from data analysis are in line with the research literature. This research indicates that divorce can be predicted based on early maladaptive schema. In accordance with early maladaptive schema approach, a model of divorce prevention and marital therapy can be developed, and also the result of this research can be applied in clinical and counseling environments to help problematic couples and the couples being on the threshold of divorce.