A new differential quadrature method based on cubic B-spline is developed for the numerical solution of differential equations. In order to develop the new approach, the B-spline basis functions are used on the grid and midpoints of a uniform partition. Some error bounds are obtained by help of cubic spline collocation, which show that the method in its classic form is second order convergent. In order to derive higher accuracy, high order perturbations of the problem are generated and applied to construct the numerical algorithm. A new fourth order method is developed for the numerical solution of systems of second order ordinary differential equations. By solving some test problems, the performance of the proposed methods is examined. Also the implementation of the method for multi-dimensional time dependent partial differential equations is presented. The stability of the proposed methods is examined via matrix analysis. To demonstrate the applicability of the algorithms, we solve the 2D and 3D coupled Burgers’ equations and 2D sine-Gordon equation as test problems. Also the coefficient matrix of the methods for multi-dimensional problems is described to analyze the stability.