A novel magnetic graphene oxide-based molecularly imprinted polymer (MGMIP) was prepared and used as an artificial receptor for creatinine (Cre) [1, 2]. A sol–gel process was used in present magnetic graphene oxide nano particle to prepare the MIP. Tetraethoxysilane (TEOS) was employed as the crosslinker for the formation of a silica matrix for the MIP. Aluminum ion (Al3+) was chosen as the dopant to generate Lewis acid sites in the silica matrix for interactions with Cre. Adsorption experiments were carried out to examine the effect of pH, time and initial concentration of cre, isotherms and sorption kinetics on the adsorption of cre by MGMIP. The MGMIP showed 97% loading efficiency with a remarkable affinity for Cre and its imprinting efficiency compared with the corresponding non-imprinted polymer (NIP). The use of MGMIP can be a cheap procedure with less time consumption and easy way for measuring Cre in blood.
