Purpose This study investigated the effects of SportsMetrics neuromuscular training programs on core strength, balance and performance of female athletes with ligament dominance. Methods Eighty-four female athletes (30 volleyball, 30 basketball and 24 soccer players) with ligament dominance were equally divided into training group (TG) and control group (CG). The TG underwent SportsMetrics neuromuscular trainings for 6 weeks, while the CG kept up with their regular trainings. The Tuck jump, McGill’s, Y Balance, T and Illinois agility, speed tests 20-yard and 40-yard, and vertical jump tests were used to assess the ligament dominance, core strength, balance, agility, speed and lower extremity power. Results The ANCOVA test exhibited a significant enhancement in core strength of soccer (p=0.01, η2=0.60) and volleyball (p = 0.01, η2 = 0.51) players, dynamic balance of soccer (p = 0.01, η2 = 0.74) and basketball (p = 0.01, η2 = 0.60) players, agility of soccer (p = 0.01, η2 = 0.54), basketball (p = 0.01, η2 = 0.27), and volleyball (p = 0.01, η2 = 0.40), speed of soccer (p = 0.01, η2 = 0.52), basketball (p = 0.04, η2 = 0.16) and volleyball (p = 0.03, η2 = 0.17) players, and jump height of soccer (p = 0.01, η2 = 0.39), basketball (p = 0.02, η2 = 0.21), and volleyball (p = 0.01, η2 = 0.36) players. Knee abduction angles significantly decreased in soccer (p < 0.01, ƞ2 = 0.71), basketball (p < 0.01, ƞ2 = 0.42) and volleyball (p < 0.01, ƞ2 = 0.76) players after SportsMetrics neuromuscular training programs. Conclusion Application of SportsMetrics neuromuscular training programs either modifies the knee injury risk factors or enhances performance among female athletes with ligament dominance. Female athletes with ligament dominance are recommended to incorporate sport-specific SportsMetrics neuromuscular training programs into their training programs.