فرنوش خسروبخش

Cholestasis is characterized by impaired bile flow, resulting in the accumulation of bile acids within hepatocytes and in the serum. Toxic bile acids induce hepatocellular injury, followed by inflammation, liver fibrosis, and cirrhosis, leading to portal hypertension and liver failure. Pharmacological therapy is limited, and patients with end-stage cholestasis usually require liver transplantation. Mitochondrial impairment is hypothesized to contribute to the pathogenesis of chronic cholestatic liver diseases. Evidence has suggested that decreasing mitochondrial fission significantly diminished the liver injury and fibrosis after bile duct ligation.