Herein, we report the synthesis and application of mesoporous siliceous MCM-41-nPr-NHSO3H, which was characterized by XRD, IR, TGA and nitrogen physisorption measurements. MCM-41-nPr-NHSO3H was used as an efficient heterogeneous catalyst for the one-pot synthesis of imidazoles derivatives under solvent free conditions with good to excellent yields. The present methodology offers several advantages such as lesswaste, simplicity of procedure, short reaction time, easy and quick isolation of the products.